IGF-1LR3 1MG

IGF-1LR3, a recombinant form of human Insulin-like Growth Factor 1 (IGF-1), is a peptide used exclusively in academic, clinical, and industrial research applications. This product is a purified, lyophilized peptide designed for molecular biology studies investigating growth factor signaling pathways, cell proliferation, and related biochemical processes.

Research Context

Insulin-like Growth Factor 1 (IGF-1) plays a critical role in cellular growth, differentiation, and metabolism. The ligand-receptor 3 (LR3) domain, often used in recombinant constructs, enhances peptide stability and specificity in experimental settings. IGF-1LR3 variants are frequently employed in in vitro studies, including cell line transfections, receptor binding assays, and functional assays to elucidate growth factor interactions.

Research Overview

IGF-1LR3 1MG is a high-purity peptide reagent intended for research applications involving the examination of IGF-1-mediated signaling mechanisms. This particular formulation leverages the LR3 domain to improve solubility and receptor binding efficiency, facilitating more accurate data in biochemical studies. The peptide is often used in tandem with labeled or unlabeled IGF-1 antibodies, growth factor receptor constructs, or downstream signaling pathway assays to assess ligand binding affinity, receptor activation, and intracellular signaling cascades.

Key Research Focus Areas

• Study of IGF-1 binding to type 1 IGF receptors (IGF-1R) and downstream signaling pathways in cellular models.
• Investigations into the role of IGF-1LR3 in enhancing peptide stability during storage and incubation.
• Comparison of IGF-1LR3-mediated effects against wild-type IGF-1 in receptor-dependent cell proliferation assays.
• Assessment of peptide specificity in competitive binding assays with other growth factors (e.g., IGF-2, IGFBP-3).
• Development of recombinant protein libraries incorporating IGF-1LR3 domains for high-throughput screening.

Product Details

The IGF-1LR3 1MG product is supplied as a lyophilized powder. Upon reconstitution, the peptide solution is optimized for use in buffer systems compatible with protein analysis techniques, including UV-Vis spectroscopy, SDS-PAGE, and enzyme-linked immunoassays. Users must ensure proper handling, storage at −20°C, and dilution according to experimental requirements. Residual solvents and impurities are strictly controlled to meet research-grade purity standards.

Safety and Handling

While IGF-1LR3 1MG is designed for research use only, standard laboratory biosafety protocols must be followed. Peptides may elicit allergic responses in some research personnel; therefore, appropriate protective measures, including gloves and lab coats, should be employed. Users should conduct initial dose-response experiments to determine optimal conditions for their specific application. This product is not intended for therapeutic, diagnostic, or cosmetic purposes and should not be administered to animals or humans.

For research use only. Not for human or animal consumption.